My PhD studies focus on developing a novel human pluripotent stem cell derived 3D neuromuscular junction on a chip. Many existing models have limitations: 2D in vitro models lack structural context and do not allow for the study of muscle contraction and function, while animal models often fail to accurately represent human genetic backgrounds and exhibit different pathophysiological characteristics when modelling neuromuscular diseases. We hypothesize that a human induced pluripotent stem cell (hiPSC)-derived 3D NMJ on a chip model can bridge this gap and can propel in vitro NMJ and neuromuscular disease research to the next level. Ultimately we intend to use the 3D NMJ to model neuromuscular disorders and screen potential treatments.

My supervisors are Dr. Maartje Huijbers, Prof. Dr. Willeke van Roon-Mom and Dr. Jessica de Greef.

My project is connected to www.huijberslab.org.