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Dr. Jessica de Greef
Dr. Jessica de Greef
Senior Researcher

Dr. Jessica de Greef

Expertises

  • FSHD
  • Genetica
  • Moleculaire Biologie

Locatie

  • Leiden UMC
    Expertisecentrum

    Leiden UMC

    South Holland Meer informatie
Senior Researcher

Dr. Jessica de Greef

Promotie:
19 Nov 2009, Studies of the Epigenetic Disease Mechanism in FSHD

I have a strong background in genetics, with specific training and expertise in muscular dystrophies. During my PhD training in the laboratory of Dr. Silvère van der Maarel (Department of Human Genetics, Leiden University Medical Center), I have contributed to unraveling the epigenetic disease mechanism of FSHD, showing that chromatin relaxation of the D4Z4 repeat array (loss of DNA methylation and loss of H3K9me3 and HP1γ/cohesin binding to the D4Z4 repeat array) is an important factor in FSHD pathogenesis. Furthermore, my PhD research showed that FSHD2 shares clinical features and epigenetic changes at D4Z4 with FSHD1, and I contributed to the hallmark study that showed that digenic inheritance of an SMCHD1 mutation and a 4qA chromosome causes FSHD2. Next, I was a postdoctoral fellow in the laboratory of Howard Hughes Medical Investigator Dr. Kevin Campbell (Department of Molecular Physiology and Biophysics, University of Iowa). Here, I studied the role of collagen VI in skeletal muscle pathology and function. This research involved histological and functional analysis of skeletal muscles from different muscular dystrophy mouse models. The skills I obtained as a PhD student in Leiden and as a postdoctoral fellow in Iowa City, I am using in my current position as a senior researcher in the department of Human Genetics at the Leiden University Medical Center. My research focuses on in vitro(muscle-on-chip) and in vivo(transgenic mouse) models for FSHD that can be used to study the disease mechanism and to test therapeutic options.

Onderzoeken

    • Leiden UMC
    • Radboud UMC
    01 Sep 2017

    The function of DUX4 in non-muscle tissues

    Meer informatie
    • Leiden UMC
    • Radboud UMC
    01 Jul 2018

    FSHD: Hypermorphic SMCHD1 variants

    Meer informatie
    • Leiden UMC
    • Erasmus MC
    • Radboud UMC
    01 Mar 2018

    Muscle-on-a-chip model for FSHD

    Meer informatie
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