The topic of my PhD research is understanding the clinical, cellular and molecular heterogeneity of Myotonic Dystrophy type 1. Myotonic Dystrophy type 1 is a hereditary neuromuscular disease that clinically manifests in a broad range of multisystem symptoms. The occurrence and seriousness of these symptoms vary between individual patients, as well as the course of the disease. This clinical heterogeneity results in difficulties for predicting individual disease progression, adapting clinical care and making progress in finding working therapies. Therefore, we aim to gain more insight in the clinical heterogeneity by investigating the cellular and molecular heterogeneity on a deeper level. To accomplish this, we will collect patient material and link the deducted cellular and molecular information to the clinical phenotypes. My PhD supervisors are Karin Faber (Maastricht UMC+, Neurology), Hilde Braakman (RadboudUMC, Neurology), Karlien Mul (RadboudUMC, Neurology) and Peter-Bram ‘t Hoen (RadboudUMC, Medical Biosciences).